… for bladder cancer [17,44], the appropriate inhibition … CYP2A13 might stop the metabolism
of some aromatic amines from smoke (eg, 4-aminobiphenyl) that is metabolized by CYP2A13 …

… undergoes metabolic activation to N-hydroxy-4-aminobiphenyl … found in TP53 in human
bladder tumors the present study used … Data are expressed as the percentage of absorbance per …

… such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to
form … For example, a recent report showed that CYP2A13 expressed in the urinary bladder …

… of NNK metabolites in the human urine has been linked to … of expressed CYP2A13 in human
lungs and the rates of NNK … : Novel mechanistic insights using 4aminobiphenyl as a model …

… CYP2A13 is a highly expressed enzyme in the lungs and mucosa and is involved in the
metabolism of … , ovary, and coronary endothelial cells, with a notable presence in the bladder. …

… expressed in the human liver, while CYP2A13 is mostly … The most effective enzyme in the
metabolic activation of 4-(… clinicopathologic characteristics of bladder cancer in Central China. …

… and drug metabolism, and “exotic CYPs” expressed in specific … CYP2A6 and CYP2A13 may
prevent the activation of tobacco… , notably in the lung and bladder, induction of inflammatory …

… to nicotine addiction to metabolically activated carcinogens to … at its 5′ position by
CYP2A6 and CYP2A13, resulting in the … ; aromatic amines such as 4-aminobiphenyl and 2-…

… of drug and xenobiotic metabolism due to its high expression levels of CYPs, and therefore
HepG2 is frequently used as an alternative model system to primary human hepatocytes [65]. …

… majorities of precarcinogens demand metabolic transformation (activation), which allows
them to interact with molecules, like DNA and protein. The metabolism of food precarcinogens …